Towards a safe and efficient clinical implementation of machine learning in radiation oncology by exploring model interpretability, explainability and data-model dependency. Phys Med Biol. 2022 05 27; 67(11). Barragán-Montero A, Bibal A, Dastarac MH, Draguet C, Valdés G, Nguyen D, Willems S, Vandewinckele L, Holmström M, Löfman F, Souris K, Sterpin E, Lee JA. PMID: 35421855.

BioDiaNucPhy

Prospective Clinical Validation of Virtual Patient-Specific Quality Assurance of Volumetric Modulated Arc Therapy Radiation Therapy Plans. Int J Radiat Oncol Biol Phys. 2022 Aug 01; 113(5):1091-1102. Wall PDH, Hirata E, Morin O, Valdes G, Witztum A. PMID: 35533908.

NeoRadRad

Artificial Intelligence-Guided Prediction of Dental Doses Before Planning of Radiation Therapy for Oropharyngeal Cancer: Technical Development and Initial Feasibility of Implementation. Adv Radiat Oncol. 2022 Mar-Apr; 7(2):100886. Chan JW, Hohenstein N, Carpenter C, Pattison AJ, Morin O, Valdes G, Thompson M, Perkins J, Perkins J, Solberg TD, Yom SS. PMID: 35387423; PMCID: PMC8977910.

View in: PubMed   Mentions: 1  

Representational Gradient Boosting: Backpropagation in the Space of Functions. IEEE Trans Pattern Anal Mach Intell. 2021 Dec 23; PP. Valdes G, Friedman J, Jiang F, Gennatas E. PMID: 34941500.

Med

Risks and Opportunities to Ensure Equity in the Application of Big Data Research in Public Health. Annu Rev Public Health. 2022 04 05; 43:59-78. Wesson P, Hswen Y, Valdes G, Stojanovski K, Handley MA. PMID: 34871504; PMCID: PMC8983486.

Pub

The Conditional Super Learner. IEEE Trans Pattern Anal Mach Intell. 2021 Dec 01; PP. Valdes G, Interian Y, Gennatas E, Van der Laan M. PMID: 34851823.

Med

An artificial intelligence framework integrating longitudinal electronic health records with real-world data enables continuous pan-cancer prognostication. Nat Cancer. 2021 07; 2(7):709-722. Morin O, Vallières M, Braunstein S, Ginart JB, Upadhaya T, Woodruff HC, Zwanenburg A, Chatterjee A, Villanueva-Meyer JE, Valdes G, Chen W, Hong JC, Yom SS, Solberg TD, Löck S, Seuntjens J, Park C, Lambin P. PMID: 35121948.

View in: PubMed   Mentions: 4  Translation:Humans

A situational awareness Bayesian network approach for accurate and credible personalized adaptive radiotherapy outcomes prediction in lung cancer patients. Phys Med. 2021 Jul; 87:11-23. Luo Y, Jolly S, Palma D, Lawrence TS, Tseng HH, Valdes G, McShan D, Ten Haken RK, Ei Naqa I. PMID: 34091197; PMCID: PMC8284560.

BioMedPhy

Salvage High-Dose-Rate Brachytherapy for Recurrent Prostate Cancer After Definitive Radiation. Pract Radiat Oncol. 2021 Nov-Dec; 11(6):515-526. Wu SY, Wong AC, Shinohara K, Roach M, Cunha JAM, Valdes G, Hsu IC. PMID: 34077809.

NeoRad

Artificial intelligence for prediction of measurement-based patient-specific quality assurance is ready for prime time. Med Phys. 2021 06; 48(6):2701-2704. Valdes G, Adamson J, Cai J. PMID: 33797761.

BioPhyRadRad

Use of Receiver Operating Curve Analysis and Machine Learning With an Independent Dose Calculation System Reduces the Number of Physical Dose Measurements Required for Patient-Specific Quality Assurance. Int J Radiat Oncol Biol Phys. 2021 03 15; 109(4):1086-1095. Hasse K, Scholey J, Ziemer BP, Natsuaki Y, Morin O, Solberg TD, Hirata E, Valdes G, Witztum A. PMID: 33197530.

NeoRadRad

Targeted transfer learning to improve performance in small medical physics datasets. Med Phys. 2020 Dec; 47(12):6246-6256. Romero M, Interian Y, Solberg T, Valdes G. PMID: 33007112.

BioPhyRadRad

Integration of AI and Machine Learning in Radiotherapy QA. Front Artif Intell. 2020; 3:577620. Chan MF, Witztum A, Valdes G. PMID: 33733216; PMCID: PMC7861232.

View in: PubMed   Mentions: 8  

Machine learning for radiation outcome modeling and prediction. Med Phys. 2020 Jun; 47(5):e178-e184. Luo Y, Chen S, Valdes G. PMID: 32418338.

BioPhyRadRad

Reply to Nock and Nielsen: On the work of Nock and Nielsen and its relationship to the additive tree. Proc Natl Acad Sci U S A. 2020 04 21; 117(16):8694-8695. Valdes G, Luna JM, Gennatas ED, Ungar LH, Eaton E, Diffenderfer ES, Jensen ST, Simone CB, Friedman JH, Solberg TD. PMID: 32265277; PMCID: PMC7183189.

Sci

Expert-augmented machine learning. Proc Natl Acad Sci U S A. 2020 03 03; 117(9):4571-4577. Gennatas ED, Friedman JH, Ungar LH, Pirracchio R, Eaton E, Reichmann LG, Interian Y, Luna JM, Simone CB, Auerbach A, Delgado E, van der Laan MJ, Solberg TD, Valdes G. PMID: 32071251; PMCID: PMC7060733.

Sci

Building more accurate decision trees with the additive tree. Proc Natl Acad Sci U S A. 2019 10 01; 116(40):19887-19893. Luna JM, Gennatas ED, Ungar LH, Eaton E, Diffenderfer ES, Jensen ST, Simone CB, Friedman JH, Solberg TD, Valdes G. PMID: 31527280; PMCID: PMC6778203.

Sci

Integrated models incorporating radiologic and radiomic features predict meningioma grade, local failure, and overall survival. Neurooncol Adv. 2019 May-Dec; 1(1):vdz011. Morin O, Chen WC, Nassiri F, Susko M, Magill ST, Vasudevan HN, Wu A, Vallières M, Gennatas ED, Valdes G, Pekmezci M, Alcaide-Leon P, Choudhury A, Interian Y, Mortezavi S, Turgutlu K, Bush NAO, Solberg TD, Braunstein SE, Sneed PK, Perry A, Zadeh G, McDermott MW, Villanueva-Meyer JE, Raleigh DR. PMID: 31608329; PMCID: PMC6777505.

View in: PubMed   Mentions: 31

Optimizing beam models for dosimetric accuracy over a wide range of treatments. Phys Med. 2019 Feb; 58:47-53. Chen J, Morin O, Weethee B, Perez-Andujar A, Phillips J, Held M, Kearney V, Han DY, Cheung J, Chuang C, Valdes G, Sudhyadhom A, Solberg T. PMID: 30824149.

BioMedPhy

Predicting radiation pneumonitis in locally advanced stage II-III non-small cell lung cancer using machine learning. Radiother Oncol. 2019 04; 133:106-112. Luna JM, Chao HH, Diffenderfer ES, Valdes G, Chinniah C, Ma G, Cengel KA, Solberg TD, Berman AT, Simone CB. PMID: 30935565.

NeoRad

Erratum: "Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers" [Med. Phys. 45 (7), 3449-3459 (2018)]. Med Phys. 2019 Feb; 46(2):1080-1087. Deist TM, Dankers FJWM, Valdes G, Wijsman R, Hsu IC, Oberije C, Lustberg T, van Soest J, Hoebers F, Jochems A, El Naqa I, Wee L, Morin O, Raleigh DR, Bots W, Kaanders JH, Belderbos J, Kwint M, Solberg T, Monshouwer R, Bussink J, Dekker A, Lambin P. PMID: 30730570.

BioPhyRadRad

In Reply to Gensheimer and Trister. Int J Radiat Oncol Biol Phys. 2018 12 01; 102(5):1594-1596. Valdes G, Chang AJ, Cunnan A, Solberg TD, Hsu IC, Interian Y, Owen K, Jensen ST, Ungar LH. PMID: 31014789.

NeoRadRad

The application of artificial intelligence in the IMRT planning process for head and neck cancer. Oral Oncol. 2018 12; 87:111-116. Kearney V, Chan JW, Valdes G, Solberg TD, Yom SS. PMID: 30527225.

Neo

Artificial Intelligence in Radiation Oncology Imaging. Int J Radiat Oncol Biol Phys. 2018 11 15; 102(4):1159-1161. Thompson RF, Valdes G, Fuller CD, Carpenter CM, Morin O, Aneja S, Lindsay WD, Aerts HJWL, Agrimson B, Deville C, Rosenthal SA, Yu JB, Thomas CR. PMID: 30353870.

NeoRadRad

Preoperative and postoperative prediction of long-term meningioma outcomes. PLoS One. 2018; 13(9):e0204161. Gennatas ED, Wu A, Braunstein SE, Morin O, Chen WC, Magill ST, Gopinath C, Villaneueva-Meyer JE, Perry A, McDermott MW, Solberg TD, Valdes G, Raleigh DR. PMID: 30235308; PMCID: PMC6147484.

MedSci

An unsupervised convolutional neural network-based algorithm for deformable image registration. Phys Med Biol. 2018 09 17; 63(18):185017. Kearney V, Haaf S, Sudhyadhom A, Valdes G, Solberg TD. PMID: 30109996.

BioDiaNucPhy

A Deep Look Into the Future of Quantitative Imaging in Oncology: A Statement of Working Principles and Proposal for Change. Int J Radiat Oncol Biol Phys. 2018 11 15; 102(4):1074-1082. Morin O, Vallières M, Jochems A, Woodruff HC, Valdes G, Braunstein SE, Wildberger JE, Villanueva-Meyer JE, Kearney V, Yom SS, Solberg TD, Lambin P. PMID: 30170101.

NeoRadRad

Machine learning and modeling: Data, validation, communication challenges. Med Phys. 2018 Oct; 45(10):e834-e840. El Naqa I, Ruan D, Valdes G, Dekker A, McNutt T, Ge Y, Wu QJ, Oh JH, Thor M, Smith W, Rao A, Fuller C, Xiao Y, Manion F, Schipper M, Mayo C, Moran JM, Ten Haken R. PMID: 30144098; PMCID: PMC6181755.

BioPhyRadRad

Exploratory analysis using machine learning to predict for chest wall pain in patients with stage I non-small-cell lung cancer treated with stereotactic body radiation therapy. J Appl Clin Med Phys. 2018 Sep; 19(5):539-546. Chao HH, Valdes G, Luna JM, Heskel M, Berman AT, Solberg TD, Simone CB. PMID: 29992732; PMCID: PMC6123157.

BioPhy

Machine learning algorithms for outcome prediction in (chemo)radiotherapy: An empirical comparison of classifiers. Med Phys. 2018 Jul; 45(7):3449-3459. Deist TM, Dankers FJWM, Valdes G, Wijsman R, Hsu IC, Oberije C, Lustberg T, van Soest J, Hoebers F, Jochems A, El Naqa I, Wee L, Morin O, Raleigh DR, Bots W, Kaanders JH, Belderbos J, Kwint M, Solberg T, Monshouwer R, Bussink J, Dekker A, Lambin P. PMID: 29763967; PMCID: PMC6095141.

BioPhyRadRad

Artificial intelligence in radiation oncology: A specialty-wide disruptive transformation? Radiother Oncol. 2018 12; 129(3):421-426. Thompson RF, Valdes G, Fuller CD, Carpenter CM, Morin O, Aneja S, Lindsay WD, Aerts HJWL, Agrimson B, Deville C, Rosenthal SA, Yu JB, Thomas CR. PMID: 29907338.

NeoRad

Clinical Applications of Quantitative 3-Dimensional MRI Analysis for Pediatric Embryonal Brain Tumors. Int J Radiat Oncol Biol Phys. 2018 11 15; 102(4):744-756. Hara JH, Wu A, Villanueva-Meyer JE, Valdes G, Daggubati V, Mueller S, Solberg TD, Braunstein SE, Morin O, Raleigh DR. PMID: 30108003.

NeoRadRad

The Future of Artificial Intelligence in Radiation Oncology. Int J Radiat Oncol Biol Phys. 2018 10 01; 102(2):247-248. Thompson RF, Valdes G, Fuller CD, Carpenter CM, Morin O, Aneja S, Lindsay WD, Aerts HJWL, Agrimson B, Deville C, Rosenthal SA, Yu JB, Thomas CR. PMID: 30191856.

NeoRadRad

Deep nets vs expert designed features in medical physics: An IMRT QA case study. Med Phys. 2018 Jun; 45(6):2672-2680. Interian Y, Rideout V, Kearney VP, Gennatas E, Morin O, Cheung J, Solberg T, Valdes G. PMID: 29603278.

BioPhyRadRad

Machine Learning in Radiation Oncology: Opportunities, Requirements, and Needs. Front Oncol. 2018; 8:110. Feng M, Valdes G, Dixit N, Solberg TD. PMID: 29719815; PMCID: PMC5913324.

View in: PubMed   Mentions: 24  

Comment on 'Deep convolutional neural network with transfer learning for rectum toxicity prediction in cervical cancer radiotherapy: a feasibility study'. Phys Med Biol. 2018 03 15; 63(6):068001. Valdes G, Interian Y. PMID: 29424369.

BioDiaNucPhy

Salvage HDR Brachytherapy: Multiple Hypothesis Testing Versus Machine Learning Analysis. Int J Radiat Oncol Biol Phys. 2018 07 01; 101(3):694-703. Valdes G, Chang AJ, Interian Y, Owen K, Jensen ST, Ungar LH, Cunha A, Solberg TD, Hsu IC. PMID: 29709315.

NeoRadRad

Correcting TG 119 confidence limits. Med Phys. 2018 Mar; 45(3):1001-1008. Kearney V, Solberg T, Jensen S, Cheung J, Chuang C, Valdes G. PMID: 29360150.

BioPhyRadRad

Clinical decision support of radiotherapy treatment planning: A data-driven machine learning strategy for patient-specific dosimetric decision making. Radiother Oncol. 2017 12; 125(3):392-397. Valdes G, Simone CB, Chen J, Lin A, Yom SS, Pattison AJ, Carpenter CM, Solberg TD. PMID: 29162279.

NeoRad

IMRT QA using machine learning: A multi-institutional validation. J Appl Clin Med Phys. 2017 Sep; 18(5):279-284. Valdes G, Chan MF, Lim SB, Scheuermann R, Deasy JO, Solberg TD. PMID: 28815994; PMCID: PMC5874948.

BioPhy

The relative accuracy of 4D dose accumulation for lung radiotherapy using rigid dose projection versus dose recalculation on every breathing phase. Med Phys. 2017 Mar; 44(3):1120-1127. Valdes G, Lee C, Tenn S, Lee P, Robinson C, Iwamoto K, Low D, Lamb JM. PMID: 28019649.

BioPhyRadRad

MediBoost: a Patient Stratification Tool for Interpretable Decision Making in the Era of Precision Medicine. Sci Rep. 2016 11 30; 6:37854. Valdes G, Luna JM, Eaton E, Simone CB, Ungar LH, Solberg TD. PMID: 27901055; PMCID: PMC5129017.

Sci

Using machine learning to predict radiation pneumonitis in patients with stage I non-small cell lung cancer treated with stereotactic body radiation therapy. Phys Med Biol. 2016 08 21; 61(16):6105-20. Valdes G, Solberg TD, Heskel M, Ungar L, Simone CB. PMID: 27461154; PMCID: PMC5491385.

BioDiaNucPhy

A mathematical framework for virtual IMRT QA using machine learning. Med Phys. 2016 Jul; 43(7):4323. Valdes G, Scheuermann R, Hung CY, Olszanski A, Bellerive M, Solberg TD. PMID: 27370147.

BioPhyRadRad

Use of TrueBeam developer mode for imaging QA. J Appl Clin Med Phys. 2015 07 08; 16(4):322–333. Valdes G, Morin O, Valenciaga Y, Kirby N, Pouliot J, Chuang C. PMID: 26219002; PMCID: PMC5690025.

BioPhy

Tumor control probability and the utility of 4D vs 3D dose calculations for stereotactic body radiotherapy for lung cancer. Med Dosim. 2015; 40(1):64-9. Valdes G, Robinson C, Lee P, Morel D, Low D, Iwamoto KS, Lamb JM. PMID: 25542785.

Rad

Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector. Cancer Gene Ther. 2014 Oct; 21(10):405-410. Takahashi M, Valdes G, Hiraoka K, Inagaki A, Kamijima S, Micewicz E, Gruber HE, Robbins JM, Jolly DJ, McBride WH, Iwamoto KS, Kasahara N. PMID: 25301172; PMCID: PMC4246057.

GenNeoThe

The high-affinity maltose switch MBP317-347 has low affinity for glucose: implications for targeting tumors with metabolically directed enzyme prodrug therapy. Chem Biol Drug Des. 2014 Mar; 83(3):266-71. Valdes G, Schulte RW, Ostermeier M, Iwamoto KS. PMID: 24131788.

BioPha

Re-evaluation of cellular radiosensitization by 5-fluorouracil: high-dose, pulsed administration is effective and preferable to conventional low-dose, chronic administration. Int J Radiat Biol. 2013 Oct; 89(10):851-62. Valdes G, Iwamoto KS. PMID: 23607451.

Rad

Effects of gamma radiation on phase behaviour and critical micelle concentration of Triton X-100 aqueous solutions. Journal of Colloid and Interface Science. 2007; 311:253:261. Valdés G, S. Rodríguez-Calvo, M. Rapado-Paneque, A. Pérez-Gramatges, F. A. Fernández, E. Frota, C. Ribeiro.